Abstract

Methadone is a controlled drug and can be prescribed by an authorized person in charge, under the direction of medical practitioners, for particular patients, to cure their addiction to opioid substances. The development and evaluation of a methadone dispenser present a prototype solution for solving the current manual methadone dispensing problems, which are prone to human error, with the implementation of the methadone maintenance treatment (MMT) program at the same time to increase public awareness about this program. In the current study, the performance of a methadone dispenser is evaluated by investigating the simulation analysis, feasibility, and efficiency of the device as compared to the manual technique. For testing purposes, methadone syrup was replicated with sugar solution of 66.6 g/50 mL at 25°C with a dynamic viscosity of 36.680 mPa.s. Thus, it was quantified that the time taken to dispense the sugar solution by using the methadone dispenser has shown a significant improvement of 81.40 % time reductions as compared to the manual technique. The low repeatability percentage of the methadone dispenser by 1.64 % contributes to a high precision device that is reliable enough to be implemented in the MMT program with a dispensing accuracy increment of 3.87 %, as compared to the manual technique. The findings suggest that the methadone dispenser is reliable and feasible and contributes to error reduction for implementation in the MMT program with approximately ≈ 97 % efficiency.

References

1.
Mohamad
N.
,
Abu Bakar
N. H.
,
Musa
N.
,
Talib
N.
, and
Ismail
R.
, “
Better Retention of Malaysian Opiate Dependents Treated with High Dose Methadone in Methadone Maintenance Therapy
,”
Harm Reduction Journal
7
, no. 
1
(December
2010
): 30, https://doi.org/10.1186/1477-7517-7-30
2.
Frimpong
J. A.
,
Shiu-Yee
K.
, and
D’aunno
T.
, “
The Role of Program Directors in Treatment Practices: The Case of Methadone Dose Patterns in US Outpatient Opioid Agonist Treatment Programs
,”
Health Services Research
52
, no. 
5
(October
2017
):
1881
1907
, https://doi.org/10.1111/1475-6773.12558
3.
Lamin
R. A. C.
,
Othman
C. N.
, and
Othman
N.
, “
Behavioral Study on Methadone Maintenance Therapy Awareness amongst Public in Malaysian Hospital
,”
Procedia-Social and Behavioral Sciences
101
(November
2013
):
159
169
, https://doi.org/10.1016/j.sbspro.2013.07.189
4.
Singh
D.
,
Chawarski
M. C.
,
Schottenfeld
R.
, and
Vicknasingam
B.
, “
Substance Abuse and the HIV Situation in Malaysia
,”
Journal of Food and Drug Analysis
21
, no. 
4
(December
2013
):
S46
S51
, https://doi.org/10.1016/j.jfda.2013.09.033
5.
Ahadani
M. A.
,
De Silva
L. C.
,
Petra
I.
,
Hameed
M. F. A
.
, and
Wong
T. S.
, “
Low Cost Robotic Medicine Dispenser
,”
Procedia Engineering
41
(
2012
):
202
209
, https://doi.org/10.1016/j.proeng.2012.07.163
6.
Hoadley
D.
and
Ananthan
A.
, “
Using Modeling and Simulation in the Design of Closed-Loop Insulin Delivery System
,”
Journal of Medical Devices
7
, no. 
2
(June
2013
): 020923, https://doi.org/10.1115/1.4024340
7.
James
K. L.
,
Barlow
D.
,
McArtney
R.
,
Hiom
S.
,
Roberts
D.
, and
Whittlesea
C.
, “
Incidence, Type and Causes of Dispensing Errors: A Review of the Literature
,”
International Journal of Pharmacy Practice
17
, no. 
1
(February
2009
):
9
30
, https://doi.org/10.1211/ijpp.17.1.0004
8.
Tsai
P.-H.
,
Chen
T.-Y.
,
Yu
C.-R.
,
Shih
C.-S.
, and
Liu
J. W. S.
, “
Smart Medication Dispenser: Design, Architecture and Implementation
,”
IEEE Systems Journal
5
, no. 
1
(March
2011
):
99
110
, https://doi.org/10.1109/JSYST.2010.2070970
9.
Petro
J. A.
,
Pawluk
D. T. V.
,
Burch
D. S.
, and
Owen
J. M.
, “
An Automated Drug Delivery Tracking Device Utilizing RFID Technology
,”
Journal of Medical Devices
3
, no. 
3
(September
2009
): 034502, https://doi.org/10.1115/1.3192105
10.
Salmasi
S.
,
Khan
T. M.
,
Hong
Y. H.
,
Ming
L. C.
, and
Wong
T. W.
, “
Medication Errors in the Southeast Asian Countries: A Systematic Review
,”
PLoS One
10
, no. 
9
(September
2015
): e0136545, https://doi.org/10.1371/journal.pone.0136545
11.
Bazazi
A. R.
,
Zelenev
A.
,
Fu
J. J.
,
Yee
I.
,
Kamarulzaman
A.
, and
Altice
F. T.
, “
High Prevalence of Non-Fatal Overdose among People who Inject Drugs in Malaysia: Correlates of Overdose and Implications for Overdose Prevention from a Cross-sectional Study
,”
International Journal of Drug Policy
26
, no. 
7
(July
2015
):
675
681
, https://doi.org/10.1016/j.drugpo.2014.11.010
12.
West
J.
,
Matthews
E.
, and
Anderson
O.
, “
Designing Out Medical Error (DOME)
,”
Journal of Medical Devices
7
, no. 
2
(June
2013
): 020926, https://doi.org/10.1115/1.4024323
13.
Moore
B. A.
,
Fazzino
T.
,
Barry
D. T.
,
Fiellin
D. A.
,
Cutter
C. J.
,
Schottenfeld
R. S.
, and
Ball
S. A.
, “
The Recovery Line: A Pilot Trial of Automated, Telephone-based Treatment for Continued Drug Use in Methadone Maintenance
,”
Journal of Substance Abuse Treatment
45
, no. 
1
(
2013
):
63
69
, https://doi.org/10.1016/j.jsat.2012.12.011
14.
Jungen
H.
,
Andresen-Streichert
H.
,
Müller
A.
, and
Iwersen-Bergmann
S.
, “
Disaccharides in Urine Samples as Markers of Intravenous Abuse of Methadone and Buprenorphine
,”
Journal of Analytical Toxicology
37
, no. 
9
(November/December
2013
):
652
658
, https://doi.org/10.1093/jat/bkt086
15.
Donaldson
M.
,
Goodchild
J. H.
, and
Epstein
J. B.
, “
Sugar Content, Cariogenicity, and Dental Concerns with Commonly Used Medications
,”
The Journal of the American Dental Association
146
, no. 
2
(February
2015
):
129
133
, https://doi.org/10.1016/j.adaj.2014.10.009
16.
Lintzeris
N.
and
Nielsen
S.
, “
Benzodiazepines, Methadone and Buprenorphine: Interactions and Clinical Management
,”
The American Journal on Addictions
19
, no. 
1
(January/February
2010
):
59
72
, https://doi.org/10.1111/j.1521-0391.2009.00007.x
17.
Chou
R.
,
Weimer
M. B.
, and
Dana
T.
, “
Methadone Overdose and Cardiac Arrhythmia Potential: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline
,”
The Journal of Pain
15
, no. 
4
(April
2014
):
338
365
, https://doi.org/10.1016/j.jpain.2014.01.495
18.
Slowinski
B.
and
Nadolny
K.
, “
Effective Manufacturing Method for Automated Inside Diameter Grinding
,”
Journal of Advanced Mechanical Design, Systems, and Manufacturing
1
, no. 
4
(September
2007
):
472
480
, https://doi.org/10.1299/jamdsm.1.472
19.
Zhang
J.
, “
Reliability Analysis of Spherical Function Generating Mechanisms
,”
Journal of Advanced Mechanical Design, Systems, and Manufacturing
8
, no. 
1
(March
2014
): JAMDSM0007, https://doi.org/10.1299/jamdsm.2014jamdsm0007
20.
Nakagawa
S.
and
Schielzeth
H.
, “
Repeatability for Gaussian and Non-Gaussian Data: A Practical Guide for Biologists
,”
Biological Reviews
85
, no. 
4
(November
2010
):
935
956
.
21.
Horie
K.
,
Tsutsumi
Y.
,
Takao
Y.
, and
Suzuki
T.
, “
Calculation of Repeatability and Reproducibility for Qualitative Data
,”
National Sun Yat-sen University
,
2008
. http://web.archive.org/web/20190731154618/http://bm.nsysu.edu.tw/tutorial/iylu/ANQ%202008/11.%20Session%20G/G5-01.doc
This content is only available via PDF.
You do not currently have access to this content.