Past nuclear accidents demonstrated that radioactive materials from an accident in a nuclear power station (NPS) can disperse to other countries or even across the globe. This means all countries need to be prepared to respond to a nuclear power emergency even if they have no nuclear power program. This study aims to propose a structured framework to enable transboundary radio activity monitoring of accidental releases in external NPSs in such a country with limited calculation resources. A trial calculation of a hypothetical release from an interfacing system loss of coolant accident (ISLOCA) in Unit 1 of Fangchenggang NPS during different representative meteorological scenarios is carried out to demonstrate the usability of the proposed framework. It was found that a relatively large release can reach the border of Thailand within 24 h when the wind along the dispersion pathway is basically in northeast direction with significant amount of rainfall, though it may not be able to trigger the alarm at the radiation monitoring stations. However, it is highly likely that the release that fulfills the aforementioned conditions be detected by one of the stations within 48 h-timeframe. As the trial calculation could deliver insightful findings with limited calculation resources, the proposed transboundary atmospheric dispersion calculation framework can be used in other nonnuclear power countries to prepare for emergency response to accidents in external NPSs.