A reverse oscillatory flow (ROF) mixing system is discussed having a reaction channel 460 μm high by 152 mm wide for high flow rate processing of nanoparticle (NP) chemistries. The ROF system is demonstrated to produce CdS nanoparticles at a production rate of 115.7 g/h with a coefficient of variation (CV) for particle size down to 19%. These production rates are substantially higher than those achieved using other microchannel mixers while maintaining comparable size distributions. Advantages of the ROF approach include the use of larger microchannels which make the reactor easier to fabricate and less vulnerable to clogging.
Issue Section:
Research Papers
References
1.
Tiwari
, S. K.
, and Paul
, B. K.
, 2008
, “Application of Nickel Nanoparticles in Diffusion Bonding of Stainless Steel Surfaces
,” ASME International Manufacturing Science and Engineering Conference
, Vol. 2
, pp. 441
–446
, Paper No. MSEC_ICMP2008-72151.2.
Peterson
, D. A.
, Apte
, S. V.
, Narayanan
, V.
, and Schmitt
, J.
, “Numerical Modeling of Mini/Microchannel Reactor for Methane-Steam Reforming
,” ASME 2010 Fluids Engineering Summer Meeting
, Montreal, QC, Canada.3.
Coakley
, K. M.
, and McGehee
, M. D.
, 2004
, “Conjugated Polymer Photovoltaic Cells
,” Chem. Mater.
, 16
, pp. 4533
–4542
.10.1021/cm049654n4.
Cho
, K.
, Wang
, X. U.
, Nie
, S.
, and Shin
, D. M.
, 2008
, “Therapeutic Nanoparticles for Drug Delivery in Cancer
,” Clin. Cancer Res.
, 14
, pp. 1310
–1316
.10.1158/1078-0432.CCR-07-14415.
Chang
, C. H.
, Paul
, B. K.
, Remcho
, V. T.
, Atre
, S.
, and Hutchison
, J. E.
, 2007
, “Synthesis and Post-Processing of Nanomaterials Using Microreaction Technology
,” J. Nanopart. Res.
, 10
, pp. 965
–980
.10.1007/s11051-007-9355-y6.
Kumar
, D. V. R.
, Kasture
, M.
, Prabhune
, A. A.
, Ramana
, C. V.
, Prasad
, B. L. V.
, and Kulkarni
, A. A.
, 2010
, “Continuous Flow Synthesis of Functionalized Silver Nanoparticles Using Bifunctional Biosurfactants
,” Green Chem.
, 12
, pp. 609
–615
.10.1039/b919550e7.
Nguyen
, N.-T.
, and Wu
, Z.
, 2005
, “Micromixers—A Review
,” J. Micromech. Microeng.
, 15
(2), pp. R1
–R16
.10.1088/0960-1317/15/2/R018.
Peterson
, D. A.
, Palanisamy
, B.
, Eluri
, R. T.
, Padmavathi
, C.
, and Paul
, B. K.
, 2013
, “Continuous-Flow, High Production Rate, Liquid-Phase Synthesis of Nanoparticles
,” Dekker Encyclopedia of Nanoscience and Nanotechnology
, Sergey Edward Lyshevski, ed., Taylor & Francis Group
, New York.9.
Shalom
, D.
, Wootton
, R. C.
, Winkle
, R. F.
, Cottam
, B. F.
, Vilar
, R.
, Demello
, A. J.
, and Wilde
, C. P.
, 2007
, “Synthesis of Thiol Functionalized Gold Nanoparticles Using a Continuous Flow Microfluidic Reactor
,” Mater. Lett.
, 61
, pp. 1146
–1150
.10.1016/j.matlet.2006.06.07210.
Tsunoyama
, H.
, Ichikuni
, N.
, and Tsukuda
, T.
, 2008
, “Microfluidic Synthesis and Catalytic Application of PVP-Stabilized, ∼1 nm Gold Clusters
,” Langmuir
, 24
, pp. 11327
–11330
.10.1021/la801372j11.
Luty-Blocho
, M.
, Fitzner
, K.
, Hessel
, V.
, Löb
, P.
, Maskos
, M.
, Metzke
, D.
, and Wojnicki
, M.
, 2011
, “Synthesis of Gold Nanoparticles in an Interdigital Micromixer Using Ascorbic Acid and Sodium Borohydride as Reducers
,” Chem. Eng. J.
, 171
, pp. 279
–290
.10.1016/j.cej.2011.03.10412.
Jin
, H. D.
, Garrison
, A.
, Tseng
, T.
, Paul
, B. K.
, and Chang
, C. H.
, 2010
, “High-Rate Synthesis of Phosphine-Stabilized Undecagold Nanoclusters Using a Multilayered Micromixer
,” Nanotechnology
, 21
, p. 445604
.10.1088/0957-4484/21/44/44560413.
Hoffmann
, M.
, Schlüter
, M.
, and Räbiger
, N.
, 2006
, “Experimental Investigation of Liquid–Liquid Mixing in T-Shaped Micro-Mixers Using μμ-LIF and μμ-PIV
,” Chem. Eng. Sci.
, 61
, pp. 2968
–2976
.10.1016/j.ces.2005.11.02914.
Glasgow
, I.
, and Aubry
, N.
, 2003
, “Enhancement of Microfluidic Mixing Using Time Pulsing
,” Lab Chip
, 3
, pp. 114
–120
.10.1039/b302569a15.
Khan
, S. A.
, Günther
, A.
, Schmidt
, M. A.
, and Jensen
, K. F.
, 2004
, “Microfluidic Synthesis of Colloidal Silica
,” Langmuir
, 20
, pp. 8604
–8611
.10.1021/la049901216.
Sugano
, K.
, Yoshimune
, H.
, Nakata
, A.
, Hirai
, Y.
, Tsuchiya
, T.
, and Tabata
, O.
, 2011
, “High-Speed Pulsed Mixing With High-Frequency Switching of Micropump Driving and Its Application to Nanoparticle Synthesis
,” 16th International Conference on Solid-State Sensors, Actuators and Microsystems Conference
, Beijing, June 5–9, pp. 1773
–1776
.17.
LaMer
, V. K.
, and Dinegar
, R. H.
, 1950
, “Theory, Production and Mechanism of Formation of Monodispersed Hydrosols
,” J. Am. Chem. Soc.
, 72
, pp. 4847
–4854
.10.1021/ja01167a00118.
Zhao
, H.
, Wang
, J. X.
, Wang
, Q. A.
, Chen
, J. F.
, and Yun
, J.
, 2007
, “Controlled Liquid Antisolvent Precipitation of Hydrophobic Pharmaceutical Nanoparticles in a Microchannel Reactor
,” Ind. Eng. Chem. Res.
, 46
, pp. 8229
–8235
.10.1021/ie070498e19.
Schwarzer
, H.-C.
, and Peukert
, W.
, 2004
, “Combined Experimental/Numerical Study on the Precipitation of Nanoparticles
,” AIChE J.
, 50
, pp. 3234
–3247
.10.1002/aic.1027720.
Robb
, D. T.
, and Privman
, V.
, 2008
, “Model of Nanocrystal Formation in Solution by Burst Nucleation and Diffusional Growth
,” Langmuir
, 24
, pp. 26
–35
.10.1021/la702097g21.
Mullaugh
, K. M.
, and Luther
, G. W.
, 2010
, “Growth Kinetics and Long-Term Stability of CdS Nanoparticles in Aqueous Solution Under Ambient Conditions
,” J. Nanopart. Res.
, 13
, pp. 393
–404
.10.1007/s11051-010-0045-922.
Huang
, F.
, Zhang
, H.
, and Banfield
, J. F.
, 2003
, “Two-Stage Crystal-Growth Kinetics Observed During Hydrothermal Coarsening of Nanocrystalline ZnS
,” Nano Lett.
, 3
, pp. 373
–378
.10.1021/nl025836+23.
Christian
, P.
, and O'Brien
, P.
, 2008
, “Thermodynamic and Kinetic Control of Crystal Growth in CdS Nanomaterials
,” J. Mater. Chem.
, 18
, pp. 1689
–1693
.10.1039/b717656b24.
Bilecka
, I.
, and Niederberger
, M.
, 2010
, “Microwave Chemistry for Inorganic Nanomaterials Synthesis
,” Nanoscale
, 2
, pp. 1358
–1374
.10.1039/b9nr00377k25.
Jahn
, A.
, Reiner
, J. E.
, Vreeland
, W. N.
, DeVoe
, D. L.
, Locascio
, L. E.
, and Gaitan
, M.
, 2008
, “Preparation of Nanoparticles by Continuous-Flow Microfluidics
,” J. Nanopart. Res.
, 10
, pp. 925
–934
.10.1007/s11051-007-9340-526.
Shayeganfar
, F.
, Javidpour
, L.
, Taghavinia
, N.
, Reza Rahimi Tabar
, M.
, Sahimi
, M.
, and Bagheri-Tar
, F.
, 2010
, “Controlled Nucleation and Growth of CdS Nanoparticles by Turbulent Dispersion
,” Phys. Rev. E
, 81
, p. 026304
.10.1103/PhysRevE.81.02630427.
Sounart
, T. L.
, Safier
, P. A.
, Voigt
, J. A.
, Hoyt
, J.
, Tallant
, D. R.
, Matzke
, C. M.
, and Michalske
, T. A.
, 2007
, “Spatially-Resolved Analysis of Nanoparticle Nucleation and Growth in a Microfluidic Reactor
,” Lab Chip
, 7
, pp. 908
–915
.10.1039/b703810k28.
Edel
, J. B.
, and Mello
, A. J.
, 2003
, “Single Particle Confocal Fluorescence Spectroscopy in Microchannels: Dependence of Burst Width and Burst Area Distributions on Particle Size and Flow Rate
,” Anal. Sci.
, 19
, pp. 1065
–1069
.10.2116/analsci.19.106529.
Hung
, L.-H.
, Choi
, K. M.
, Tseng
, W. Y.
, Tan
, Y. C.
, Shea
, K. J.
, and Lee
, A. P.
, 2006
, “Alternating Droplet Generation and Controlled Dynamic Droplet Fusion in Microfluidic Device for CdS Nanoparticle Synthesis
,” Lab Chip
, 6
, pp. 174
–178
.10.1039/b513908b30.
Valencia
, P. M.
, Basto
, P. A.
, Zhang
, L.
, Rhee
, M.
, Langer
, R.
, Farokhzad
, O. C.
, and Karnik
, R.
, 2010
, “Single-Step Assembly of Homogenous Lipid-Polymeric and Lipid-Quantum Dot Nanoparticles Enabled by Microfluidic Rapid Mixing
,” ACS Nano
, 4
, pp. 1671
–1679
.10.1021/nn901433u31.
Peterson
, D. A.
, Palanisamy
, B.
, Eluri
, R. T.
, Padmavathi
, C.
, and Paul
, B. K.
, 2013
, “Micromixing Strategies for Continuous-Flow Liquid-Phase Reacting Chemistries
,” Dekker Encyclopedia of Nanoscience and Nanotechnology
, Taylor & Francis Group
, New York.32.
Engler
, M.
, 2004
, “Numerical and Experimental Investigations on Liquid Mixing in Static Micromixers
,” Chem. Eng. J.
, 101
, pp. 315
–322
.10.1016/j.cej.2003.10.01733.
Kockmann
, N.
, Kiefer
, T.
, Engler
, M.
, and Woias
, P.
, 2006
, “Convective Mixing and Chemical Reactions in Microchannels With High Flow Rates
,” Sens. Actuators, B
, 117
, pp. 495
–508
.10.1016/j.snb.2006.01.00434.
Bothe
, D.
, Stemich
, C.
, and Warnecke
, H. J.
, 2008
, “Computation of Scales and Quality of Mixing in a T-Shaped Microreactor
,” Comput. Chem. Eng.
, 32
, pp. 108
–114
.10.1016/j.compchemeng.2007.08.00135.
Ehrfeld
, W.
, Golbig
, K.
, Hessel, V., Löwe
, H.
, and Richter
, T.
, 1999
, “Characterization of Mixing in Micromixers by a Test Reaction: Single Mixing Units and Mixer Arrays
,” Ind. Eng. Chem. Res
, 38
, pp. 1075
–1082
.10.1021/ie980128d36.
Adeosun
, J. T.
, and Lawal
, A.
, 2005
, “Mass Transfer Enhancement in Microchannel Reactors by Reorientation of Fluid Interfaces and Stretching
,” Sens. Actuators, B
, 110
, pp. 101
–111
.10.1016/j.snb.2005.01.01637.
Sugano
, K.
, Uchida
, Y.
, Ichihashi
, O.
, Yamada
, H.
, Tsuchiya
, T.
, and Tabata
, O.
, 2010
, “Mixing Speed-Controlled Gold Nanoparticle Synthesis With Pulsed Mixing Microfluidic System
,” Microfluid. Nanofluid.
, 9
, pp. 1165
–1174
.10.1007/s10404-010-0637-938.
Peterson
, D. A.
, Garrison
, A. E.
, and Paul
, B. K.
, 2011
, “Evaluation of a Reverse Oscillatory Flow Microreactor Design for the Synthesis of Uniformly-Sized Nanoparticles
,” International Manufacturing Science and Engineering Conference
, Corvallis, OR.39.
Peterson
, D. A.
, 2010
, “Numerical Simulation of Micro/Mini-Channel Based Methane-Steam Reformer
,” M.S. thesis, Department of Mechanical Engineering, Oregon State University, Corvallis, OR.40.
Wong
, S.
, Ward
, M. C.
, and Wharton
, C. W.
, 2004
, “Micro T-Mixer as a Rapid Mixing Micromixer
,” Sens. Actuators, B
, 100
, pp. 359
–379
.10.1016/j.snb.2004.02.00841.
Chang
, C. C.
, and Yang
, R. J.
, 2004
, “Computational Analysis of Electrokinetically Driven Flow Mixing in Microchannels With Patterned Blocks
,” J. Micromech. Microeng.
, 14
, pp. 550
–558
.10.1088/0960-1317/14/4/01642.
Yang
, J.-T.
, Huang
, K. J.
, and Lin
, Y. C.
, 2005
, “Geometric Effects on Fluid Mixing in Passive Grooved Micromixers
,” Lab Chip
, 5
, pp. 1140
–1147
.10.1039/b500972c43.
Bothe
, D.
, Stemich
, C.
, and Warnecke
, H. J.
, 2006
, “Fluid Mixing in a T-Shaped Micro-Mixer
,” Chem. Eng. Sci.
, 61
, pp. 2950
–2958
.10.1016/j.ces.2005.10.06044.
Kurian
, P. A.
, Vijayan
, C.
, Sathiyamoorthy
, K.
, Sandeep
, C. S.
, and Philip
, R.
, 2007
, “Excitonic Transitions and Off-Resonant Optical Limiting in CdS Quantum Dots Stabilized in a Synthetic Glue Matrix
,” Nanoscale Res. Lett.
, 2
(11
), pp. 561
–568
.10.1007/s11671-007-9099-845.
Edelstein
, A. S.
, and Cammaratra
, R. C.
, 1998
, Nanomaterials: Synthesis, Properties and Applications
, Vol. 1
, CRC Press
, New York.46.
Seoudi
, R.
, Shabaka
, A. A.
, Kamal
, M.
, Abdelrazek
, E. M.
, and Eisa
, W.
, 2012
, “Dependence of Spectroscopic and Electrical Properties on the Size of Cadmium Sulfide Nanoparticles
,” Physica E
, 45
, pp. 47
–55
.10.1016/j.physe.2012.07.006Copyright © 2014 by ASME
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