Abstract

Two cases of suicide involving colchicine are examined. Colchicine and colchicum preparations have been used for the relief of pain in acute gout and are reported to be effective for the treatment of periodic peritonitis. A method using enzymatic digestion, extraction, and high pressure liquid chromatographic analysis for the extraction and analysis of colchicine in autopsy specimens is described.

References

1.
Arena
,
J. M.
,
Poisoning
, 4th ed.,
Charles C Thomas
,
Springfield, IL
,
1979
, pp.
412
413
.
2.
Henry
,
T. A.
,
The Plant Alkaloids
, 3rd ed.,
J. & A. Churchill Ltd.
,
London
,
1939
.
3.
Martindale—The Extra Pharmacopoeia
,
A.
Wade
, Ed., 26th ed.,
Pharmaceutical Press
,
London
,
1977
, pp.
448
450
.
4.
Goodman
,
L. S.
and
Gilman
,
A.
,
The Pharmacological Basis of Therapeutics
, 4th ed.,
Collier-Macmillan Ltd.
,
London
,
1970
.
5.
Creasy
,
W. A.
,
Drug Disposition in Humans—The Basis of Clinical Pharmacology
,
Oxford University Press
,
New York
,
1979
, pp.
180
182
.
6.
Fleischmann
,
W.
,
Price
,
H.
, and
Fleischmann
,
S.
,
Medical Pharmacology and Experimental Therapeutics
, Vol.
12
,
1965
, pp.
172
176
.
7.
King
,
J. S.
,
Journal of American Pharmacology Association
, Vol.
40
, No.
9
,
1951
, pp.
424
427
.
8.
Boudene
,
C.
,
Duprez
,
F.
, and
Bohuon
,
C.
,
Biochemical Journal
, Vol.
151
,
1975
, pp.
413
415
.
9.
Caplan
,
Y.
,
Orloff
,
K.
, and
Thompson
,
B. J.
,
Analytical Toxicology
, Vol.
4
,
1980
, pp.
153
155
.
10.
Jarvie
,
D.
,
Park
,
J.
, and
Stewart
,
M.
,
Clinical Toxicology
, Vol.
14
,
1979
, pp.
375
381
.
11.
Osselton
,
M. D.
,
Hammond
,
M. D.
, and
Twitchett
,
P. J.
,
Journal of Pharmacy and Pharmacology
, Vol.
29
,
1977
, p. 460.
12.
Stahl
,
E.
,
Thin-Layer Chromatography—A Laboratory Handbook
, 2nd ed.,
Springer-Verlag
,
Heidelberg
,
1969
, pp.
425
430
.
This content is only available via PDF.
You do not currently have access to this content.