Abstract
Two cases of suicide involving colchicine are examined. Colchicine and colchicum preparations have been used for the relief of pain in acute gout and are reported to be effective for the treatment of periodic peritonitis. A method using enzymatic digestion, extraction, and high pressure liquid chromatographic analysis for the extraction and analysis of colchicine in autopsy specimens is described.
Issue Section:
Research Papers
References
1.
Arena
, J. M.
, Poisoning
, 4th ed., Charles C Thomas
, Springfield, IL
, 1979
, pp. 412
–413
.2.
Henry
, T. A.
, The Plant Alkaloids
, 3rd ed., J. & A. Churchill Ltd.
, London
, 1939
.3.
Martindale—The Extra Pharmacopoeia
, A.
Wade
, Ed., 26th ed., Pharmaceutical Press
, London
, 1977
, pp. 448
–450
.4.
Goodman
, L. S.
and Gilman
, A.
, The Pharmacological Basis of Therapeutics
, 4th ed., Collier-Macmillan Ltd.
, London
, 1970
.5.
Creasy
, W. A.
, Drug Disposition in Humans—The Basis of Clinical Pharmacology
, Oxford University Press
, New York
, 1979
, pp. 180
–182
.6.
Fleischmann
, W.
, Price
, H.
, and Fleischmann
, S.
, Medical Pharmacology and Experimental Therapeutics
, Vol. 12
, 1965
, pp. 172
–176
.7.
King
, J. S.
, Journal of American Pharmacology Association
, Vol. 40
, No. 9
, 1951
, pp. 424
–427
.8.
Boudene
, C.
, Duprez
, F.
, and Bohuon
, C.
, Biochemical Journal
, Vol. 151
, 1975
, pp. 413
–415
.9.
Caplan
, Y.
, Orloff
, K.
, and Thompson
, B. J.
, Analytical Toxicology
, Vol. 4
, 1980
, pp. 153
–155
.10.
Jarvie
, D.
, Park
, J.
, and Stewart
, M.
, Clinical Toxicology
, Vol. 14
, 1979
, pp. 375
–381
.11.
Osselton
, M. D.
, Hammond
, M. D.
, and Twitchett
, P. J.
, Journal of Pharmacy and Pharmacology
, Vol. 29
, 1977
, p. 460.12.
Stahl
, E.
, Thin-Layer Chromatography—A Laboratory Handbook
, 2nd ed., Springer-Verlag
, Heidelberg
, 1969
, pp. 425
–430
.
This content is only available via PDF.
All rights reserved. This material may not be reproduced or copied, in whole or in part, in any printed, mechanical, electronic, film, or other distribution and storage media, without the written consent of ASTM International.
You do not currently have access to this content.