Abstract
Results are presented of a comprehensive drug study carried out on specimens from drivers and pedestrians fatally injured in Ontario. Toxicological analyses were regularly performed on blood and urine and occasionally on vitreous humor, stomach contents, and liver. The analytical procedures could detect and quantitate a wide variety of drugs including such illicit drugs as Cannabis. With respect to drivers, alcohol was found in 57% of the study sample and drugs other than alcohol, in 26%. However, in only 9.5% of the drivers were psychoactive drugs (other than alcohol) detected in the blood in concentrations that may adversely affect driving skills. Δ-9-Tetrahydrocannabinol and diazepam accounted for a majority of the findings in this category.
Issue Section:
Research Papers
References
1.
Woodhouse
, E. J.
, “The Incidence of Drugs in Fatally Injured Drivers
,” Midwest Research Institute Report PB-230948, Kansas City, MO, 02
1974
.2.
Turk
, R. F.
, McBay
, A. J.
, and Hudson
, P.
, “Drug Involvement in Automobile Driver and Pedestrian Fatalities
,” Journal of Forensic Sciences
, Vol. 19
, No. 1
, 01
1974
, pp. 90
–97
.3.
Garriott
, J. C.
, DiMaio
, V. J. M.
, Zumwalt
, R. E.
, and Petty
, C. S.
, “Incidence of Drugs and Alcohol in Fatally Injured Motor Vehicle Drivers
,” Journal of Forensic Sciences
, Vol. 22
, No. 2
, 04
1977
, pp. 383
–389
.4.
Machata
, G.
, “Determination of Alcohol in Blood by Gas Chromatographic Headspace Analysis
,” Clinical Chemistry Newsletter
, Vol. 4
, No. 2
, Winter1972
, pp. 29
–32
.5.
Yen
, B.
and Cimbura
, G.
, “Comparison of the UV Differential and the GLC Methods for the Quantitation of Barbituates in Blood
,” Canadian Society of Forensic Science Journal
Vol. 9
, No. 3
, 09
1976
, pp. 113
–116
.6.
Wells
, J.
, Cimbura
, G.
, and Koves
, E.
, “The Screening of Blood by Gas Chromatography for Basic and Neutral Drugs
,” Journal of Forensic Sciences
, Vol. 20
, No. 2
, 04
1975
, pp. 382
–390
.7.
Wells
, J.
and Cimbura
, G.
, “Street Drugs and the Forensic Toxicologist
,” Proceedings of the International Symposium on Instrumental Applications in Forensic Drug Chemistry
, U.S. Government Printing Office
, Washington, DC
, 1978
, pp. 214
–220
.8.
Clarke
, E. G. C.
, Isolation and Identification of Drugs
, Vol. 1
, The Pharmaceutical Press
, London
, 1969
.9.
Lucas
, G. H. W.
and Fabierkiewicz
, C.
, “Useful Tests to Identify Phenothiazine Tranquilizers
,” Journal of Forensic Sciences
, Vol. 8
, No. 3
, 07
1963
, pp. 462
–476
.10.
Simpson
, E.
and Stewart
, M. J.
, “Screening for Paracetamol Poisoning
,” Annals of Clinical Biochemistry
, Vol. 10
, 1973
, pp. 171
–172
.11.
Finkle
, B. S.
and Bath
, R.
, in Methodology for Analytical Toxicology
, I.
Sunshine
, Ed., C.R.C. Press
, Cleveland
, 1975
, p. 155.12.
Cimbura
, G.
, in Methodology for Analytical Toxicology
, I.
Sunshine
, Ed., C.R.C. Press
, Cleveland
, 1975
, p. 192.13.
Kananen
, G.
, in Methodology for Analytical Toxicology
, I.
Sunshine
, Ed., C.R.C. Press
, Cleveland
, 1975
, pp. 75
–76
.14.
Rosenthal
, D.
and Brine
, D.
, “Quantitative Determination of Delta-9-Tetrahydrocannabinol in Cadaver Blood
,” Journal of Forensic Sciences
, Vol. 24
, No. 2
, 04
1979
, pp. 282
–290
.15.
Williams
, L. A.
, Linn
, R. A.
, and Zak
, B.
, “Differential UV Spectrophotometric Determination of Serum Salicylates
,” Journal of Laboratory and Clinical Medicine
, Vol. 53
, No. 1
, 01
1959
, pp. 156
–162
.16.
Morwitz
, R. A.
and Jatlow
, P. I.
, “Determination of Acetaminophen in Serum by High Pressure Liquid Chromatography
,” Clinical Chemistry
, Vol. 23
, No. 9
, 09
1977
, pp. 1596
–1598
.17.
Peat
, M. A.
and Kopjak
, L.
, “The Screening and Quantitation of Diazepam, Flurazepam, Chlordiazepoxide and Their Metabotites in Blood and Plasma by Electron-Capture Gas Chromatography and High Pressure Liquid Chromatography
,” Journal of Forensic Sciences
, Vol. 24
, No. 1
, 01
1979
, pp. 46
–54
.18.
Willett
, R. E.
, Ed., Cannabinoid Assays in Humans
, Research Monograph 7, National Institute on Drug Abuse
, Rockville, MD
, 1976
.19.
Owen
, S. M.
, McBay
, A. J.
, Reisner
, H. M.
, and Perez-Reyes
, M.
, “125I Radioimmunoassay of Delta-9-Tetrahydrocannabinol in Blood and Plasma with a Solid-Phase Second-Antibody Separation Method
,” Clinical Chemistry
, Vol. 27
, No. 4
, 04
1981
, pp. 619
–624
.20.
Goodman
, L. S.
and Gilman
, A.
, The Pharmacological Basis of Therapeutics
, 6th ed., MacMillan Publishing Co., Inc.
, New York
, 1980
, p. 562.21.
Speaker
, J. H.
, “General Tranquilizers
,” in Drugs and Driving
, R. E.
Willett
, Ed., Research Monograph 11, National Institute on Drug Abuse
, Rockville, MD
, 1978
, pp. 39
–43
.22.
Hillestad
, L.
, Hansen
, T.
, and Melsom
, H.
, “Diazepam Metabolism in Normal Man
,” Clinical Pharmacology and Therapeutics
, Vol. 16
, No. 3
, 09
1974
, pp. 479
–484
.23.
Baselt
, R. C.
, Disposition of Toxic Drugs and Chemicals in Man
, Vol. 1
, Biomedical Publications
, Canton, CT
, 1978
, p. 170.24.
Bye
, C.
, Chubley
, M.
, and Peck
, A. W.
, “Drowsiness, Impaired Performance and Tricyclic Antidepressant Drugs
,” British Journal of Clinical Pharmacology
, Vol. 6
, No. 2
, 08
1978
, pp. 155
–161
.25.
Baselt
, R. C.
, Disposition of Toxic Drugs and Chemicals in Man
, Vol. 2
, Biomedical Publications
, Canton, CT
, 1978
, p. 31.26.
Broadhurst
, A. D.
, “The Effect of Propanolol on Human Psychomotor Performance
,” Aviation, Space, and Environmental Medicine
, Vol. 51
, No. 2
, 02
1980
, pp. 176
–179
.27.
Barnhart
, J. W.
and Massad
, E. N.
, “Determination of Dextromethorphan in Serum by Gas Chromatography
,” Journal of Chromatography
0021-9673, Vol. 163
, 1979
, pp. 390
–395
.28.
Goodman
, L. S.
and Gilman
, A.
, The Pharmacological Basis of Therapeutics
, 6th ed., MacMillan Publishing Co., Inc.
, New York
, 1980
, p. 529.29.
Baselt
, R. C.
, Disposition of Toxic Drugs and Chemicals in Man
, Vol. 1
, Biomedical Publications
, Canton, CT
, 1978
, p. 189.30.
Bonnischsen
, R.
, Maehly
, A. C.
, Marde
, Y.
, Ryhage
, R.
, and Schubert
, B.
, “Determination and Identification of Sympathomimetic Amines in Blood Samples from Drivers by a Combination of Gas Chromatography and Mass Spectrometry
,” Journal of Legal Medicine
, Vol. 67
, 1970
, pp. 19
–26
.31.
Chase
, A. R.
, Kelley
, P. R.
, Taunton-Rigby
, A.
, Jones
, R. T.
, and Harwood
, T.
, “Quantitation of Cannabinoids in Biological Fluids by Radiommunoassay
,” in Cannabinoid Assays in Humans
, R. E.
Willett
, Ed., Research Monograph 7, National Institute on Drug Abuse
, Rockville, MD
, 1976
, pp. 1
–9
.32.
Gross
, S. J.
and Soares
, J. R.
, “Separate Radioimmune Measurements of Body Fluid Delta-9-THC and 11-nor-9-carboxy-9-THC
,” in Cannabinoid Assays in Humans
, R. E.
Willett
, Ed., Research Monograph 7, National Institute on Drug Abuse
, Rockville, MD
, 1976
, pp. 10
–14
.
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