Abstract
Thermodynamics, the science of energy interactions, governs the direction of processes found in nature. While the subject finds wide applications in science and technology, its connection to biological sciences and in particular to bio-engineering is becoming increasingly important. In this work, after a brief introduction to the fundamental concepts in thermodynamics, we focus on its application in human physiology. A review of application of thermodynamics to the interaction between human body and environment is presented. Research works on biological systems such as the nervous system and the cardiovascular systems are summarized. The thermodynamics of metabolism is reviewed, and finally, the role of the subject in understanding and combating diseases is highlighted.
Issue Section:
Review Articles
References
1.
Edsall
,
J. T.
, 1993
, “
Master of Metabolic Cycles
,” Nature
,
366
(6454
), pp. 417
–418
.10.1038/366417a02.
Haynie
,
D. T.
, 2008
, Biological Thermodynamics
,
Cambridge University Press
,
New York
.3.
Ubbelohde, A., 1963,
Man End Energy
, Pelican Press, Great Britain, UK.4.
Pippard
,
A. B.
, 1957
, Elements of Classical Thermodynamics
,
Cambridge University Press
,
Cambridge, UK
.5.
Bunn
,
E. F.
, 2009
, “
Evolution and the Second Law of Thermodynamics
,” Am. J. Phys.
,
77
(10
), pp. 922
–925
.10.1119/1.31195136.
Bardeen
,
J. M.
,
Carter
,
B.
, and
Hawking
,
S. W.
, 1973
, “
The Four Laws of Black Hole Mechanics
,” Commun. Math. Phys.
,
31
(2
), pp. 161
–170
.10.1007/BF016457427.
Hawking
,
S.
, 1988
, A Brief History of Time
,
Bantam Doubleday Dell Publishing Group
,
UK
.8.
Choi
,
J.-H.
, and
Loftness
,
V.
, 2012
, “
Investigation of Human Body Skin Temperatures as a Bio-Signal to Indicate Overall Thermal Sensations
,” Build. Environ
,
58
, pp. 258
–269
.10.1016/j.buildenv.2012.07.0039.
Hall
,
J. E.
, 2016
, Guyton and Hall Textbook of Medical Physiology
, 13thed.,
Elsevier
, Amsterdam, The Netherlands.10.
Djongyang
,
N.
,
Tchinda
,
R.
, and
Njomo
,
D.
, 2010
, “
Thermal Comfort: A Review Paper
,” Renewable Sustainable Energy Rev.
,
14
(9
), pp. 2626
–2640
.10.1016/j.rser.2010.07.04011.
Yi
,
L.
,
Fengzhi
,
L.
,
Yingxi
,
L.
, and
Zhongxuan
,
L.
, 2004
, “
An Integrated Model for Simulating Interactive Thermal Processes in Humaneclothing System
,” J. Therm. Biol.
,
29
(7–8
), pp. 567
–575
.10.1016/j.jtherbio.2004.08.07112.
Fiala
,
D.
,
Lomas
,
K. J.
, and
Stohrer
,
M.
, 1999
, “
A Computer Model of Human Thermoregulation for a Wide Range of Environmental Conditions: The Passive System
,” J. Appl. Physiol.
,
87
(5
), pp. 1957
–1972
.10.1152/jappl.1999.87.5.195713.
Fiala
,
D.
,
Lomas
,
K. J.
, and
Stohrer
,
M.
, 2001
, “
Computer Prediction of Human Thermoregulatory and Temperature Responses to a Wide Range of Environmental Conditions
,” Int. J. Biometeorol.
,
45
(3
), pp. 143
–159
.10.1007/s00484010009914.
Havenith, G., and Fiala, D., 2015, “Thermal Indices and Thermophysiological Modelling for Heat Stress,”
Compr. Physiol.
, 6(1), pp. 255–302.10.1002/cphy.c14005115.
Huizenga
,
C.
,
Hui
,
Z.
, and
Arens
,
E.
, 2001
, “
A Model of Human Physiology and Comfort for Assessing Complex Thermal Environments
,” Build. Environ.
,
36
(6
), pp. 691
–699
.10.1016/S0360-1323(00)00061-516.
Zhang
,
H.
,
Huizenga
,
C.
,
Arens
,
E.
, and
Yu
,
T.
, 2001
, “
Considering Individual Physiological Differences in a Human Thermal Model
,” J. Therm. Biol.
,
26
(4–5
), pp. 401
–408
.10.1016/S0306-4565(01)00051-117.
Tanabe
,
S/-I.
,
Kobayashi
,
K.
,
Nakano
,
J.
,
Ozeki
,
Y.
, and
Konishi
,
M.
, 2002
, “
Evaluation of Thermal Comfort Using Combined Multi-Node Thermoregulation (65MN) and Radiation Models and Computational Fluid Dynamics (CFD)
,” Energy Build.
,
34
(6
), pp. 637
–646
.10.1016/S0378-7788(02)00014-218.
Ivanov
,
K. P.
, 2006
, “
The Development of the Concepts of Homeothermy and Thermoregulation
,” J. Therm. Biol.
,
31
(1–2
), pp. 24
–29
.10.1016/j.jtherbio.2005.12.00519.
Kingma
,
B. R. M.
,
Schellen
,
L.
,
Frijns
,
A. J. H.
, and
van Marken Lichtenbelt
,
W. D.
, 2012
, “
Thermal Sensation: A Mathematical Model Based on Neurophysiology
,” Indoor Air
,
22
(3
), pp. 253
–262
.10.1111/j.1600-0668.2011.00758.x20.
Schweiker
,
M.
,
Kingma
,
B. R. M.
, and
Wagner
,
A.
, 2017
, “
Evaluating the Performance of Thermal Sensation Prediction With a Biophysical Model
,” Indoor Air
,
27
(5
), pp. 1012
–1021
.10.1111/ina.1237221.
Jeffery
,
K.
,
Pollack
,
R.
, and
Rovelli
,
C.
, 2019
, “
On the Statistical Mechanics of Life: Schrödinger Revisited
,” Entropy
,
21
(12
), p. 1211
.10.3390/e2112121122.
Demetrius
,
L.
, 2000
, “
Thermodynamics and Evolution
,” J. Theor. Biol.
,
206
(1
), pp. 1
–16
.10.1006/jtbi.2000.210623.
Schrödinger
,
E.
, 1944
, What is Life
?,
Cambridge University Press
,
Cambridge, UK
.24.
Schneider
,
E. D.
, and
Kay
,
J. J.
, 1994
, “
Life as a Manifestation of the Second Law of Thermodynamics
,” Mathl. Comput. Modell.
,
19
(6–8
), pp. 25
–48
.10.1016/0895-7177(94)90188-025.
Bejan
,
A.
, 2015
, “
Constructal Law: Optimization as Design Evolution
,” ASME J. Heat Transfer
,
137
(6
), p. 061003
.10.1115/1.402985026.
Bejan
,
A.
, 2016a
, The Physics of Life: The Evolution of Everything
,
St. Martin's Press
,
New York
.27.
Bejan
,
A.
, and
Errera
,
M. R.
, 2016
, “
Complexity, Organization, Evolution, and Constructal Law
,” J. App. Phys.
,
119
(7
), p. 074901
.10.1063/1.494155428.
Simkin
,
A. J.
,
López-Calcagno
,
P. E.
, and
Raines
,
C. A.
, 2019
, “
Feeding the World: Improving Photosynthetic Efficiency for Sustainable Crop Production
,” J. Exp. Bot.
,
70
(4
), pp. 1119
–1140
.10.1093/jxb/ery44529.
Popovic
,
M.
, 2019
, “
Thermodynamic Properties of Microorganisms: Determination and Analysis of Enthalpy, Entropy, and Gibbs Free Energy of Biomass, Cells and Colonies of 32 Microorganism Species
,” Heliyon
,
5
(6
), p. e01950
.10.1016/j.heliyon.2019.e0195030.
Schreiber
,
A.
, and
Gimbel
,
S.
, 2010
, “
Evolution and the Second Law of Thermodynamics: Effectively Communicating to Non-Technicians
,” Evo. Edu. Outreach
,
3
(1
), pp. 99
–106
.10.1007/s12052-009-0195-331.
Turner
,
P.
,
Nottale
,
L.
,
Zhao
,
J.
, and
Pesquet
,
E.
, 2020
, “
New Insights Into the Physical Processes That Underpin Cell Division and the Emergence of Different Cellular and Multicellular Structures
,” Prog. Biophys. Mol. Biol.
,
150
, pp. 13
–42
.10.1016/j.pbiomolbio.2019.04.00632.
Arens
,
E.
, and
Zhang
,
H.
, 2006
, “
The Skin's Role in Human Thermoregulation and Comfort
,” Thermal and Moisture Transport in Fibrous Materials
,
N.
Pan
and
P.
Gibson
, eds.,
Woodhead Publishing Ltd
., Cambridge, UK, pp. 560
–602
.33.
Joyner
,
M. J.
, and
Casey
,
D. P.
, 2015
, “
Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs
,” Physiol. Rev.
,
95
(2
), pp. 549
–601
.10.1152/physrev.00035.201334.
Fanger
,
P.
, 1970
, Thermal Comfort Analysis and Applications in Environmental Engineering
,
Copenhagen Danish Technical Press
,
Copenhagen, Denmark
.35.
Katic
,
K.
,
Li
,
R.
, and
Zeiler
,
W.
, 2016
, “
Thermophysiological Models and Their Applications: A Review
,” Build. Environ.
,
106
, pp. 286
–300
.10.1016/j.buildenv.2016.06.03136.
Schellen
,
L.
,
Loomans
,
M. G. L. C.
,
Kingma
,
B. R. M.
,
de Wit
,
M. H.
,
Frijns
,
A. J. H.
, and
van Marken Lichtenbelt
,
W. D.
, 2013
, “
The Use of a Thermophysiological Model in the Built Environment to Predict Thermal Sensation
,” Build. Environ.
,
59
, pp. 10
–22
.10.1016/j.buildenv.2012.07.01037.
Tang
,
Y.
,
He
,
Y.
,
Shao
,
H.
, and
Ji
,
C.
, 2016
, “
Assessment of Comfortable Clothing Thermal Resistance Using a Multi-Scale Human Thermoregulatory Model
,” Int. J. Heat. Mass Transfer
,
98
, pp. 568
–583
.10.1016/j.ijheatmasstransfer.2016.03.03038.
Fiala
,
D.
,
Havenith
,
G.
,
Br€Ode
,
P.
,
Kampmann
,
B.
, and
Jendritzky
,
G.
, 2012
, “
UTCI-Fiala Multimode Model of Human Heat Transfer and Temperature Regulation
,” Int. J. Biometeorol.
,
56
(3
), pp. 429
–441
.10.1007/s00484-011-0424-739.
Parsons
,
K.
, 2003
, Human Thermal Environments: The Effects of Hot, Moderate and Cold Environments on Human Health, Comfort and Performance
, 2nd ed.,
Taylor & Francis
,
London & New York
.40.
Taleghani
,
M.
,
Tenpierik
,
M.
,
Kurvers
,
S.
, and
van den Dobbelsteen
,
A.
, 2013
, “
A Review Into Thermal Comfort in Buildings
,” Renewable Sustainable Energy Rev.
,
26
, pp. 201
–215
.10.1016/j.rser.2013.05.05041.
Zhu
,
L.
,
Schappeler
,
T.
,
Cordero-Tumangday
,
C.
, and
Rosengart
,
A. J.
, 2009
, “
Thermal Interactions Between Blood and Tissue: Development of a Theoretical Approach in Predicting Body Temperature During Blood Cooling/Rewarming
,” Adv. Numer. Heat Transfer
,
3
, pp. 197
–219
.https://www.researchgate.net/publication/329483057_Thermal_interactions_between_blood_and_tissue_Development_of_a_theoretical_approach_in_predicting_body_temperature_during_blood_cooling_and_Rewarming42.
Zhu
,
L.
, 2010
, “
Recent Developments in Biotransport
,” ASME J. Therm. Sci. Eng. App.
,
2
(4
), p. 040801
.43.
Shrivastava
,
D.
, and
Vaughan
,
J. T.
, 2009
, “
A Generic Bioheat Transfer Thermal Model for a Perfused Tissue
,” ASME J. Biomech. Eng.
,
131
(7
), p. 74506
.10.1115/1.312726044.
Bhowmik
,
A.
,
Repaka
,
R.
,
Mishra
,
S. C.
, and
Mitra
,
K.
, 2015
, “
Thermal Assessment of Ablation Limit of Subsurface Tumor During Focused Ultrasound and Laser Heating
,” ASME J. Therm. Sci. Eng. Appl.
,
8
(1
), p. 011012
.10.1115/1.400351145.
Mitra
,
K.
,
Kumar
,
S.
,
Vedevarz
,
A.
, and
Moallemi
,
M. K.
, 1995
, “
Experimental Evidence of Hyperbolic Heat Conduction in Processed Meat
,” ASME J. Heat Transfer
,
117
(3
), pp. 568
–573
.10.1115/1.282261546.
Dutta
,
J.
,
Kundu
,
B.
, and
Yook
,
S. J.
, 2021
, “
Three-Dimensional Thermal Assessment in Cancerous Tumors Based on Local Thermal Non-Equilibrium Approach for Hyperthermia Treatment
,” Int. J. Therm. Sci.
,
159
, p. 106591
.10.1016/j.ijthermalsci.2020.10659147.
Kundu
,
B.
, 2016
, “
Exact Analysis for Propagation of Heat in a Biological Tissue Subject to Different Surface Conditions for Therapeutic Applications
,” Appl. Math. Comput.
,
285
, pp. 204
–216
.10.1016/j.amc.2016.03.03748.
Zakharov
,
M.
, and
Sadovsky
,
M.
, 2013
, “
The Role of Blood Circulatory System in Thermal Regulation of Animals Explained by Entropy Production Analysis
,” arXiv: Other Quant. Biol.
, pp. 1
–22
. https://www.researchgate.net/publication/255965805_The_role_of_blood_circulatory_system_in_thermal_regulation_of_animals_explained_by_entropy_pr49.
Isawa
,
K.
, and
Shukuya
,
M.
, 2016
, “
Sensitivity Numerical Analysis of Human Body Exergy Balance Under an Unsteady-State Thermal Environment—Behavioral Adaptation Induced by Undesirable Cold Storage by Building Envelope in Winter
,” Health
,
08
(08
), pp. 737
–748
.10.4236/health.2016.8807750.
Vallez
,
L. J.
,
Plourde
,
B. D.
, and
Abraham
,
J. P.
, 2016
, “
A New Computational Thermal Model of the Whole Human Body: Applications to Patient Warming Blankets
,” Numer. Heat Transfer A
,
69
(3
), pp. 227
–241
.10.1080/10407782.2015.108057351.
Gorman
,
J. M.
,
Regnier
,
M.
, and
Abraham
,
J. P.
, 2020
, “
Heat Exchange Between the Human Body and the Environment: A Comprehensive, Multi-Scale Numerical Simulation
,” Adv. Heat Transfer
, 52, pp. 1
–151
.10.1016/bs.aiht.2020.07.00152.
Rahman
,
M. A.
, 2007
, “
A Novel Method for Estimating Entropy Generation Rate in Human Body
,” Therm. Sci.
,
11
(1
), pp. 75
–92
.10.2298/TSCI0701075R53.
Silva
,
C.
, and
Annamalai
,
K.
, 2008
, “
Entropy Generation and Human Aging: Lifespan Entropy and Effect of Physical Activity Level
,” Entropy
,
10
(2
), pp. 100
–123
.10.3390/entropy-e1002010054.
Silva
,
C.
, and
Annamalai
,
K.
, 2009
, “
Entropy Generation and Human Aging: Lifespan Entropy and Effect of Diet Composition and Caloric Restriction Diets
,” J. Thermodyn.
,
2009
, pp. 1
–10
.10.1155/2009/18672355.
Aoki
,
I.
, 1989
, “
Entropy Flow and Entropy Production in the Human Body in Basal Conditions
,” J. Theor. Biol.
,
141
(1
), pp. 11
–21
.10.1016/S0022-5193(89)80004-956.
Shukuya
,
M.
, 2009
, “
Exergy Concept and Its Application to the Built Environment
,” Bldg. Environ.
,
44
(7
), pp. 1545
–1550
.10.1016/j.buildenv.2008.06.01957.
Simone
,
A.
,
Kolarik
,
J.
,
Iwamatsu
,
T.
,
Asada
,
H.
,
Dovjak
,
M.
,
Schellen
,
L.
,
Shukuya
,
M.
, and
Olesen
,
B. W.
, 2011
, “
A Relation Between Calculated Human Body Exergy Consumption Rate and Subjectively Assessed Thermal Sensation
,” Energy Build.
,
43
(1
), pp. 1
–9
.10.1016/j.enbuild.2010.08.00758.
Mady
,
C. E. K.
,
Ferreira
,
M. S.
,
Yanagihara
,
J. I.
,
Oliveira Jr
,
S.
, and
Saldiva
,
P. H. N.
, 2011
, “
Second Law of Thermodynamics and Human Body
,” Therm. Eng.
,
10
(1–2
), pp. 88
–95
.10.5380/reterm.v10i1-2.6196859.
Mady
,
C. E. K.
,
Ferreira
,
M. S.
,
Yanagihara
,
J. I.
,
Saldiva
,
P. H. N.
, and
de Oliveira Junior
,
S.
, 2012
, “
Modeling the Exergy Behavior of Human Body
,” Energy
,
45
(1
), pp. 546
–553
.10.1016/j.energy.2012.02.06460.
Annamalai
,
K.
, and
Silva
,
C.
, 2012
, “
Entropy Stress and Scaling of Vital Organs Over Life Span Based on Allometric Laws
,” Entropy
,
14
(12
), pp. 2550
–2577
.10.3390/e1412255061.
Caliskan
,
H.
, 2013
, “
Energetic and Exergetic Comparison of the Human Body for the Summer Season
,” Energy Conv. Magmt.
,
76
, pp. 169
–176
.10.1016/j.enconman.2013.07.04562.
Mady
,
C. E. K.
,
Henriques
,
I. B.
, and
de Oliveira Junior
,
S.
, 2013
, “
Exergy Analysis of Human Body and Lifespan: A First Approach
,” 22nd International Congress of Mechanical Engineering (COBEM 2013)
, RibeirãoPreto, SP, Brazil, Nov. 3–7.https://www.researchgate.net/publication/260553406_Exergy_analysis_of_human_body_and_lifespan_a_fi_rst_approach63.
Mady
,
C. E. K.
,
Henriques
,
I. B.
, and
de Oliveira Junior
,
S.
, 2014
, “
Method to Perform Exergy Analysis to the Human Body and Daily Exergy Balance
,” 15th Brazilian Congress of Thermal Sciences and Engineering
, Belém, PA, Brazil, Nov. 10–13.https://www.researchgate.net/publication/278963312_METHOD_TO_PERFORM_EXERGY_ANALYSIS_TO_THE_HUMAN_BODY_AND_DAILY_EXERGY_BALANCE64.
Dovjak
,
M.
,
Shukuya
,
M.
, and
Krainer
,
A.
, 2015
, “
Exergetic Issues of Thermoregulation Physiology in Different Climates
,” Int. J. Exergy
,
17
(4
), pp. 412
–432
.10.1504/IJEX.2015.07155865.
Dovjak
,
M.
,
Shukuya
,
M.
, and
Krainer
,
A.
, 2015
, “
Connective Thinking on Building Envelope—Human Body Exergy Analysis
,” Int. J. Heat Mass Transfer
,
90
, pp. 1015
–1025
.10.1016/j.ijheatmasstransfer.2015.07.02166.
Schweiker
,
M.
,
Kolarik
,
J.
,
Dovjak
,
M.
, and
Shukuya
,
M.
, 2016
, “
Unsteady-State Human-Body Exergy Consumption Rate and Its Relation to Subjective Assessment of Dynamic Thermal Environments
,” Energy Build.
,
116
, pp. 164
–180
.10.1016/j.enbuild.2016.01.00267.
Prek
,
M.
, 2005
, “
Thermodynamic Analysis of Human Heat and Mass Transfer and Their Impact on Thermal Comfort
,” Int. J. Heat Mass Transfer
,
31
(5
), pp. 732
–743
.10.1016/j.ijheatmasstransfer.2004.09.00668.
Prek
,
M.
, 2006
, “
Thermodynamical Analysis of Human Thermal Comfort
,” Energy
,
31
(5
), pp. 732
–743
.10.1016/j.energy.2005.05.00169.
Prek
,
M.
, and
Butala
,
V.
, 2017
, “
Comparison Between Fanger's Thermal Comfort Model and Human Exergy Loss
,” Energy
,
138
, pp. 228
–237
.10.1016/j.energy.2017.07.04570.
Henriques
,
I. B.
,
Mady
,
C. E. K.
, and
de Oliveira Junior
,
S.
, 2017
, “
Assessment of Thermal Comfort Conditions During physical Exercise by Means of Exergy Analysis
,” Energy
,
128
, pp. 609
–617
.10.1016/j.energy.2017.04.03371.
Buyak
,
N. A.
,
Deshko
,
V. I.
, and
Sukhodub
,
I. O.
, 2017
, “
Buildings Energy Use and Human Thermal Comfort According to Energy and Exergy Approach
,” Energ. Build.
,
146
, pp. 172
–181
.10.1016/j.enbuild.2017.04.00872.
Garcia
,
M. M.
,
Une
,
R. Y.
,
de Oliveira Junior
,
S.
, and
Mady
,
C. E. K.
, 2018
, “
Exergy Analysis and Human Body Thermal Comfort Conditions: Evaluation of Different Body Compositions
,” Entropy
,
20
(4
), p. 265
.10.3390/e2004026573.
Guo
,
H.
,
Luo
,
Y.
,
Meggers
,
F.
, and
Simonetti
,
M.
, 2019
, “
Human Body Exergy Consumption Models' Evaluation and Their Sensitivities Towards Different Environmental Conditions
,” Energy
,
183
, pp. 1075
–1088
.10.1016/j.energy.2019.05.04574.
Turhan
,
C.
, and
Akkurt
,
G. G.
, 2019
, “
The Relation Between Thermal Comfort and Human-Body Exergy Consumption in a Temperate Climate Zone
,” Energy Build.
,
205
, p. 109548
.10.1016/j.enbuild.2019.10954875.
Maino
,
G.
, and
Lucia
,
U.
, 2018
, “
A Thermodynamic Approach to the Microclimate Environment of Museums
,” Phys. A
, 517, pp. 66
–72
.10.1016/j.physa.2018.08.12176.
Deshko
,
V.
,
Buyak
,
N.
,
Bilous
,
I.
, and
Voloshchuk
,
V.
, 2020
, “
Reference State and Exergy Based Dynamics Analysis of Energy Performance of the “Heat Source - Human - Building Envelope” System
,” Energy
,
200
, p. 117534
.10.1016/j.energy.2020.11753477.
Patel
,
A. K.
, and
Rajput
,
S. P. S.
, 2020
, “
Reference State and Exergy Based Dynamics Analysis of Energy Performance of the “Heat Source—Human—Building Envelope” System, “Parametric Analysis of Energy and Exergy of the Human Body in Indian Conditions
,” Int. J. Exergy,
33(3), pp. 328
–343
.10.1504/IJEX.2020.11087378.
Bit
,
A.
, and
Chattopadhyay
,
H.
, 2014
, “
Numerical Investigations of Pulsatile Flow in Stenosed Artery
,” Acta Bioeng. Biomech.
,
16
(4
), pp. 33
–44
.https://pubmed.ncbi.nlm.nih.gov/25598070/#:~:text=Method%3A%20In%20this%20work%2C%20a,pulsating%20profile%20at%20the%20inlet.&text=Two%20different%20patient%2D%20specific%20pulsatile,from%2025%25%20to%2080%25.79.
Bit
,
A.
, and
Chattopadhyay
,
H.
, 2014
, “
Assessment of Rheological Models for Prediction of Transport Phenomena in Stenosed Artery
,” Prog. Comput. Fluid Dyn.
,
14
(6
), pp. 363
–374
.10.1504/PCFD.2014.06546880.
Bit
,
A.
,
Alblawi
,
A.
,
Chattopadhyay
,
H.
,
Quais
,
Q. A.
,
Benim
,
A. C.
,
Rahimi-Gorji
,
M.
, and
Do
,
H. T.
, 2020
, “
Three Dimensional Numerical Analysis of Hemodynamic of Stenosed Artery Considering Realistic Outlet Boundary Conditions
,” Comput. Meth. Prog. Biomed.
,
185
, p. 105163
.10.1016/j.cmpb.2019.10516381.
Prokop
,
R. M.
,
Chen
,
P.
,
Garg
,
A.
, and
Neumann
,
A. W.
, 1999
, “
Thermodynamic Modelling of the Lung Mechanics
,” Colloids Surf. B: Biointerfaces
,
13
(2
), pp. 59
–73
.10.1016/S0927-7765(98)00105-282.
Bit
,
A.
,
Chattopadhay
,
H.
, and
Nag
,
D.
, 2009
, “
Study of Airflow in the Trachea of a Bronchopulmonary Patient Using CT Data
,” Ind. J. Biomech., Spec.
, pp. 31
–36
. https://www.semanticscholar.org/paper/Study-of-Airflow-in-the-Trachea-of-a-Patient-using-Bit-Chattyopadhay/601d1d78078e80e25bd14b8ba998319908e7b7f683.
Reis
,
A. H.
,
Miguel
,
A. F.
, and
Aydin
,
M.
, 2004
, “
Constructal Theory and Flow Architecture in the Lungs
,” Med. Phys.
,
31
(5
), pp. 1135
–1140
.10.1118/1.170544384.
Dutta
,
A.
,
Chattopadhyay
,
H.
, and
Biswas
,
A.
, 2019a
, “
A Comparative Study on the Entropy Generation in the Human Respiratory Tract Based on Hess-Murray Law and Weibel Experimented Result
,” J. Mech. Med. Biol.
,
19
(06
), p. 1950046
.10.1142/S021951941950046585.
Dutta
,
A.
,
Chattopadhyay
,
H.
,
Yasmin
,
H.
, and
Gorji
,
M. R.
, 2019b
, “
Entropy Generation in the Human Lung Due to Effect of Psychrometric Condition and Friction in the Respiratory Tract
,” Comput. Meth. Prog. Biomed.
,
180
, p. 105010
.10.1016/j.cmpb.2019.10501086.
Min
,
K.
, 2015
, “
Entropy Change of Lungs: Determinant of Static Properties of the Lungs
,” Appl. Math
,
06
(08
), pp. 1200
–1207
.10.4236/am.2015.6811187.
Oliveira
,
C. L. N.
,
Araújo
,
A. D.
,
Bates
,
J. H. T.
,
Andrade
,
J. S.
, Jr.
, and
Suki
,
B.
, 2016
, “
Entropy Production and the Pressure–Volume Curve of the Lung
,” Front. Physiol.
,
7
, p. 73
.10.3389/fphys.2016.0007388.
Gattinoni
,
L.
,
Tonetti
,
T.
,
Cressoni
,
M.
,
Cadringher
,
P.
,
Herrmann
,
P.
,
Moerer
,
O.
,
Protti
,
A.
,
Gotti
,
M.
,
Chiurazzi
,
C.
,
Carlesso
,
E.
,
Chiumello
,
D.
, and
Quintel
,
M.
, 2016
, “
Ventilator Related Causes of Lung Injury: The Mechanical Power
,” Intensive Care Med.
,
42
(10
), pp. 1567
–1575
.10.1007/s00134-016-4505-289.
Çatak
,
J.
,
Ozilgen
,
M.
, and
Yilmaz
,
B.
, 2018a
, “
Thermodynamic Analysis of Human Respiratory (Diaphragm) Skeletal Muscles
,” Eur. Respir. J.
,
52
(suppl 62
), p. PA2447
.10.1183/13993003.congress-2018.PA244790.
Çatak
,
J.
,
Develi
,
E.
, and
Bayram
,
S.
, 2019
, “
Comparison the Work of Breathing Between Healthy and Obese by Thermodynamic Analysis
,” Eur. Respir. J.
,
54
(suppl 63
), p. PA753
10.1183/13993003.congress-2019.PA753.91.
Dutta
,
A.
, and
Chattopadhyay
,
H.
, 2020
, “
Exergetic Analysis of Human Respiratory System Including Effect of Age and Gender
,” Int. J. Exergy
,
31
(4
), pp. 370
–385
.10.1504/IJEX.2020.10719492.
Dutta
,
A.
, and
Chattopadhyay
,
H.
, 2021
, “
Performance Analysis of Human Respiratory System Based on Second Law of Thermodynamics
,” J. Therm. Biol.
,
96
(1
), p. 102862
.10.1016/j.jtherbio.2021.10286293.
Uehara
,
M.
,
Sakane
,
K. K.
, and
Bertolotti
,
S. A.
, 2008
, “
Thermodynamics of the Heart: Relation Between Cardiac Output and Oxygen Consumption
,” Am. J. Phys.
,
76
(6
), pp. 566
–569
.10.1119/1.282539594.
Dini
,
F. L.
,
Guarini
,
G.
,
Morrone
,
D.
, and
Marzilli
,
M.
, 2012
, “
The Second Law of Thermodynamics and the Heart
,” Future Cardiol.
,
8
(5
), pp. 697
–706
.10.2217/fca.12.4595.
Henriques
,
I. B.
,
Mady
,
C. E. K.
, and
de Oliveira Junior
,
S.
, 2015
, “
Exergy Model of the Human Heart
,” Proceedings of ECOS 2015 - The 28th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems
, Pau, France, June 30–July 3.96.
Henriques
,
I. B.
,
Mady
,
C. E. K.
, and
de Oliveira Junior
,
S.
, 2016
, “
Exergy Model of the Human Heart
,” Energy
,
117
, pp. 612
–619
.10.1016/j.energy.2016.02.15097.
Dutta
,
A.
, and
Chattopadhyay
,
H.
, 2021
, “
Performance Analysis of Human Cardiorespiratory System Based on the Second Law of Thermodynamics
,” Int. J. Exergy
,
34
(1
), pp. 29
–49
.10.1504/IJEX.2021.11203498.
Kirkaldy
,
J. S.
, 1965
, “
Thermodynamics of the Human Brain
,” Biophys. J.
,
5
(6
), pp. 981
–986
.10.1016/S0006-3495(65)86763-799.
Balendiran
,
K. G.
,
Schnutgen
,
F.
,
Scapin
,
G.
,
Borchers
,
T.
,
Xhong
,
N.
,
Lim
,
K.
,
Godbout
,
R.
,
Spener
,
F.
, and
Sacchettini
,
J. C.
, 2000
, “
Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-Binding Protein
,” J. Biol. Chem.
,
275
(35
), pp. 27045
–27054
.10.1016/S0021-9258(19)61478-X100.
Varpula
,
S.
,
Annila
,
A.
, and
Beck
,
C.
, 2013
, “
Thoughts About Thinking: Cognition According to the Second Law of Thermodynamics
,” Adv. Stud. Biol.
,
5
(3
), pp. 135
–149
.10.12988/asb.2013.13012101.
Collell
,
G.
, and
Fauquet
,
J.
, 2015
, “
Brain Activity and Cognition: A Connection From Thermodynamics and Information Theory
,” Front. Psychol.
,
6
, p. 818
.10.3389/fpsyg.2015.00818102.
Wang
,
T.
,
Mužić
,
T.
,
Jackson
,
A. D.
, and
Heimburg
,
T.
, 2018
, “
The Free Energy of Biomembrane and Nerve Excitation and the Role of Anaesthetics
,” BBA-Biomembr.
,
1860
(10
), pp. 2145
–2153
.10.1016/j.bbamem.2018.04.003103.
Beshkar
,
M.
, 2018
, “
A Thermodynamic Approach to the Problem of Consciousness
,” Med. Hypothesis
,
113
, pp. 15
–16
.10.1016/j.mehy.2018.02.003104.
Poznanski
,
R. R.
,
Cacha
,
L. A.
,
Latif
,
A. Z. A.
,
Salleh
,
S. H.
,
Ali
,
J.
,
Yupapin
,
P.
,
Tuszynski
,
J. A.
, and
Tengku
,
M. A.
, 2019
, “
Theorizing How the Brain Encodes Consciousness Based on Negentropic Entanglement
,” J. Integr. Neurosci.
,
18
(1
), pp. 1
–10
.105.
Haddad
,
W. M.
,
Hui
,
Q.
, and
Bailey
,
J. M.
, 2014
, “
Human Brain Networks: Spiking Neuron Models, Multistability, Synchronization, Thermodynamics, Maximum Entropy Production, and Anesthetic Cascade Mechanisms
,” Entropy
,
16
(7
), pp. 3939
–4003
.10.3390/e16073939106.
Attwell
,
D.
, and
Laughlin
,
S. B.
, 2001
, “
An Energy Budget for Signaling in the Grey Matter of the Brain
,” J. Cereb. Blood. Flow. Metab.
,
21
(10
), pp. 1133
–1145
.10.1097/00004647-200110000-00001107.
Sengupta
,
B.
,
Stemmler
,
M. B.
, and
Friston
,
K. J.
, 2013
, “
Information and Efficiency in the Nervous System—A Synthesis
,” PLoS Comput. Biol.
,
9
(7
), p. 1003157
.10.1371/journal.pcbi.1003157108.
Louw
,
R. H.
,
Rubin
,
D. M.
,
Glasser
,
D.
,
Letts
,
R. F. R.
, and
Hildebrandt
,
D.
, 2017
, “
Thermodynamic Considerations in Renalseparation Processes
,” Theor. Biol. Med. Model.
,
14
(1
), pp. 2
–22
.10.1186/s12976-017-0048-7109.
Margulis
,
L.
, and
Sagan
,
D.
, 1998
, “
Reproductive Thermodynamics
,” Nature
,
392
(6676
), pp. 561
–561
.110.
Sanctorius
,
S.
, 2017
, Ars de StaticaMedicina
,
Franklin Classic Trade Press
.111.
Mady
,
C. E. K.
, and
de Oliveira Junior
,
S.
, 2013
, “
Human Body Exergy Metabolism
,” Int. J. Thermodyn.
,
16
(2
), pp. 73
–80
10.5541/ijot.453.112.
Batato
,
M.
,
Borel
,
L.
,
Deriaz
,
O.
, and
Jequier
,
E.
, 1990
, “
Analyse Exergétique Théorique Et Expérimentale Du Corps Humain
,” Entropy
,
26
, pp. 120
–130
.https://infoscience.epfl.ch/record/53166?ln=en113.
Genc
,
S.
,
Sorguven
,
E.
,
Kurnaz
,
I. A.
, and
Ozilgen
,
M.
, 2013
, “
Exergetic Efficiency of ATP Production in Neuronal Glucose Metabolism
,” Int. J. Exergy
,
13
(1
), pp. 60
–84
.10.1504/IJEX.2013.055778114.
Borgert
,
J. A.
, and
Moura
,
L. M.
, 2013
, “
Exergetic Analysis of Glucose Metabolism
,” Int. J. Exergy
,
12
(1
), pp. 31
–53
.10.1504/IJEX.2013.052542115.
Alberty
,
R. A.
, 2003
, Thermodynamics of Biochemical Reactions
,
Wiley
, Hoboken, NJ.116.
Lems
,
S.
,
Kooi
,
H. J. V. D.
, and
Arons
,
J. D. S.
, 2007
, “
Thermodynamic Analysis of the Living Cell: Design of an Exergy-Based Method
,” Int. J. Exergy
,
4
(4
), pp. 339
–356
.10.1504/IJEX.2007.015077117.
Ahlborg
,
G.
, and
Jensen-Urstad
,
M.
, 1991
, “
Metabolism in Exercising Arm Vs. leg Muscle
,” Clin. Physiol.
,
11
(5
), pp. 459
–468
.10.1111/j.1475-097X.1991.tb00818.x118.
Volianitis
,
S.
, and
Secher
,
N.
, 2002
, “
Arm Blood Flow and Metabolism During Arm and Combined Arm and Leg Exercise in Humans
,” J. Physiol.
,
544
(3
), pp. 977
–984
.10.1113/jphysiol.2002.023556119.
Pedersen
,
E.
,
Kozerke
,
S.
,
Ringgaard
,
S.
,
Scheidegger
,
M.
, and
Boesiger
,
P.
, 1999
, “
Quantitative Abdominal Aortic Flow Measurements at Controlled Levels of Ergometer Exercise
,” Magn. Reson. Imaging
,
17
(4
), pp. 489
–494
.10.1016/S0730-725X(98)00209-4120.
Strange
,
S.
, 1999
, “
Cardiovascular Control During Concomitant Dynamic Leg Exercise and Static Arm Exercise in Humans
,” J. Physiol.
,
514
(1
), pp. 283
–291
.10.1111/j.1469-7793.1999.283af.x121.
Brink-Elfegoun
,
T.
,
Kaijser
,
L.
,
Gustafsson
,
T.
, and
Ekblom
,
B.
, 2007
, “
Maximal Oxygen Uptake is Not Limited by a Central Nervous System Governor
,” J. App. Physiol.
,
102
(2
), pp. 781
–786
.10.1152/japplphysiol.00566.2006122.
Catak
,
J.
,
Ozilgen
,
M.
,
Olcay
,
A. B.
, and
Yilmaz
,
B.
, 2018
, “
Assessment of the Work Efficiency With Exergy Method in Ageing Muscles and Enlarged Hearts
,” Int. J. Exergy
,
25
(1
), pp. 1
–33
.10.1504/IJEX.2018.088885123.
Catak
,
J.
, 2018c
, “
Thermodynamic Analysis of Work of Breathing of Healthy Individuals and Patients With Chronic Obstructive Pulmonary Disease
,” Eur. J. Sci. Tech.
,
14
, pp. 145
–151
.10.31590/ejosat.472665124.
Thomas
,
D. M.
,
Scioletti
,
M.
, and
Heymsfield
,
S. B.
, 2019
, “
Predictive Mathematical Models of Weight Loss
,” Curr. Diabetes Rep.
,
19
, pp. 1
–7
.https://link.springer.com/article/10.1007/s11892-019-1207-5125.
Yildiz
,
C.
,
Semerciöz
,
A. S.
,
Yalçınkaya
,
B. H.
,
Denizİpek
,
T.
,
Ozturk-Isik
,
E.
, and
Özilgen
,
M.
, 2020
, “
Entropy Generation and Accumulation in Biological Systems
,” Int. J. Exergy
, 33(4), pp. 444
–468
.10.1504/IJEX.2020.111691126.
Strohman
,
R.
, 2003
, “
Thermodynamics—Old Laws in Medicine and Complex Disease
,” Nat. Biotechnol.
,
21
(5
), pp. 477
–479
.10.1038/nbt0503-477127.
Bienertová-Vašků
,
J.
,
Zlámal
,
F.
,
Nečesánek
,
I.
,
Konečný
,
D.
, and
Vasku
,
A.
, 2016
, “
Calculating Stress: From Entropy to a Thermodynamic Concept of Health and Disease
,” PLoS One
,
11
(1
), p. e0146667
.10.1371/journal.pone.0146667128.
Ferrer
,
J.
,
Prats
,
C.
,
López
,
D.
,
Vidal-Mas
,
J.
,
Gargallo-Viola
,
D.
,
Guglietta
,
A.
, and
Giró
,
A.
, 2011
, “
Thermodynamic Concepts in the Study of Microbial Populations: Age Structure in Plasmodium falciparum Infected Red Blood Cells
,” PLoS One
,
6
(10
), p. e26690
.10.1371/journal.pone.0026690129.
Lucia
,
U.
,
Grisolia
,
G.
,
Ponzetto
,
A.
,
Bergandi
,
L.
, and
Silvagno
,
F.
, 2020
, “
Thermomagnetic Resonance Affects Cancer Growth and Motility
,” R. Soc. Open Sci.
,
7
(7
), p. 200299
.10.1098/rsos.200299130.
Yilmaz
,
B.
,
Ercan
,
S.
,
Akduman
,
S.
, and
Özilgen
,
M.
, 2020
, “
Energetic and Exergetic Costs of COVID-19 Infection on the Body of a Patient
,” Int. J. Exergy
,
32
(3
), pp. 314
–327
.10.1504/IJEX.2020.108602131.
Lecarpentier
,
Y.
,
Claes
,
V.
,
Vallée
,
A.
, and
Hébert
,
J. L.
, 2017
, “
Thermodynamics in Cancers: Opposing Interactions Between PPAR Gamma and the Canonical WNT/Beta-Catenin Pathway
,” Clin. Trans. Med.
,
6
, pp. 1
–14
.10.1186/s40169-017-0144-7132.
Vallée
,
A.
,
Lecarpentier
,
Y.
,
Guillevin
,
R.
, and
Vallée
,
J. N.
, 2018
, “
Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms
,” NeuroMolecular Med.
,
20
(2
), pp. 174
–204
.10.1007/s12017-018-8486-x133.
Vallée
,
A.
,
Lecarpentier
,
Y.
,
Guillevin
,
R.
, and
Vallée
,
J. N.
, 2018
, “
Demyelination in Multiple Sclerosis: Reprogramming Energy Metabolism and Potential PPARγ Agonist Treatment Approaches
,” Int. J. Mol. Sci.
,
19
(4
), p. 1212
.10.3390/ijms19041212134.
Vallée
,
A.
,
Lecarpentier
,
Y.
,
Guillevin
,
R.
, and
Vallée
,
J. N.
, 2018
, “
Reprogramming Energetic Metabolism in Alzheimer's Disease
,” Life Sci.
,
193
, pp. 141
–152
.10.1016/j.lfs.2017.10.033135.
Tosato
,
M.
, and
Marco
,
V. D.
, 2019
, “
Metal Chelation Therapy and Parkinson's Disease: A Critical Review on the Thermodynamics of Complex Formation Between Relevant Metal Ions and Promising or Established Drugs
,” Biomolecules
,
9
(7
), p. 269
.10.3390/biom9070269136.
Fang
,
X.
, and
Wang
,
J.
, 2020
, “
Nonequilibrium Thermodynamics in Cell Biology: Extending Equilibrium Formalism to Cover Living Systems
,” Annu. Rev. Biophys.
,
49
(1
), pp. 227
–246
.10.1146/annurev-biophys-121219-081656137.
Aristov
,
V. V.
, 2019
, “
Biological Systems as Nonequilibrium Structures Described by Kinetic Methods
,” Results Phys.
,
13
, p. 102232
.10.1016/j.rinp.2019.102232138.
Zadpoor
,
A. A.
, 2015
, “
Mechanics of Biological Tissues and Biomaterials: Current Trends
,” Materials (Basel, Switzerland)
,
8
(7
), pp. 4505
–4511
.10.3390/ma8074505Copyright © 2021 by ASME
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