The Fontan operation is a palliative surgical procedure performed on children, born with congenital heart defects that have yielded only a single functioning ventricle. The total cavo-pulmonary connection (TCPC) is a common variant of the Fontan procedure, where the superior vena cava (SVC) and inferior vena cava (IVC) are routed directly into the pulmonary arteries (PA). Due to the limited pumping energy available, optimized hemodynamics, in turn, minimized power loss, inside the TCPC pathway is required for the best optimal surgical outcomes. To complement ongoing efforts to optimize the anatomical geometric design of the surgical Fontan templates, here, we focused on the characterization of power loss changes due to the temporal variations in between SVC and IVC flow waveforms. An experimentally validated pulsatile computational fluid dynamics solver is used to quantify the effect of phase-shift between SVC and IVC inflow waveforms and amplitudes on internal energy dissipation. The unsteady hemodynamics of two standard idealized TCPC geometries are presented, incorporating patient-specific real-time PC-MRI flow waveforms of “functional” Fontan patients. The effects of respiration and pulsatility on the internal energy dissipation of the TCPC pathway are analyzed. Optimization of phase-shift between caval flows is shown to lead to lower energy dissipation up to 30% in these idealized models. For physiological patient-specific caval waveforms, the power loss is reduced significantly (up to 11%) by the optimization of all three major harmonics at the same mean pathway flow (3 L/min). Thus, the hemodynamic efficiency of single ventricle circuits is influenced strongly by the caval flow waveform quality, which is regulated through respiratory dependent physiological pathways. The proposed patient-specific waveform optimization protocol may potentially inspire new therapeutic applications to aid postoperative hemodynamics and improve the well being of the Fontan patients.
Skip Nav Destination
e-mail: kpekkan@andrew.cmu.edu
Article navigation
March 2010
Research Papers
Optimization of Inflow Waveform Phase-Difference for Minimized Total Cavopulmonary Power Loss
Onur Dur,
Onur Dur
Department of Biomedical Engineering,
Carnegie Mellon University
, Pittsburgh, PA 15219
Search for other works by this author on:
Curt G. DeGroff,
Curt G. DeGroff
Congenital Heart Center,
University of Florida
, Gainesville, FL 32610
Search for other works by this author on:
Bradley B. Keller,
Bradley B. Keller
Cardiovascular Innovation Institute,
University of Louisville
, Louisville, KY 40202
Search for other works by this author on:
Kerem Pekkan
Kerem Pekkan
Assistant Professor
Department of Biomedical Engineering, and Department of Mechanical Engineering,
e-mail: kpekkan@andrew.cmu.edu
Carnegie Mellon University
, Pittsburgh, PA 15219
Search for other works by this author on:
Onur Dur
Department of Biomedical Engineering,
Carnegie Mellon University
, Pittsburgh, PA 15219
Curt G. DeGroff
Congenital Heart Center,
University of Florida
, Gainesville, FL 32610
Bradley B. Keller
Cardiovascular Innovation Institute,
University of Louisville
, Louisville, KY 40202
Kerem Pekkan
Assistant Professor
Department of Biomedical Engineering, and Department of Mechanical Engineering,
Carnegie Mellon University
, Pittsburgh, PA 15219e-mail: kpekkan@andrew.cmu.edu
J Biomech Eng. Mar 2010, 132(3): 031012 (9 pages)
Published Online: February 17, 2010
Article history
Received:
January 25, 2009
Revised:
October 13, 2009
Posted:
January 6, 2010
Published:
February 17, 2010
Online:
February 17, 2010
Citation
Dur, O., DeGroff, C. G., Keller, B. B., and Pekkan, K. (February 17, 2010). "Optimization of Inflow Waveform Phase-Difference for Minimized Total Cavopulmonary Power Loss." ASME. J Biomech Eng. March 2010; 132(3): 031012. https://doi.org/10.1115/1.4000954
Download citation file:
Get Email Alerts
Simulating the Growth of TATA-Box Binding Protein-Associated Factor 15 Inclusions in Neuron Soma
J Biomech Eng (December 2024)
Effect of Structure and Wearing Modes on the Protective Performance of Industrial Safety Helmet
J Biomech Eng (December 2024)
Sex-Based Differences and Asymmetry in Hip Kinematics During Unilateral Extension From Deep Hip Flexion
J Biomech Eng (December 2024)
Related Articles
Three-Dimensional Simulations in Glenn Patients: Clinically Based Boundary Conditions, Hemodynamic Results and Sensitivity to Input Data
J Biomech Eng (November,2011)
A Computational Fluid Dynamic (CFD) Tool for Optimization and Guided Implantation of Biomedical Devices
J. Med. Devices (June,2009)
Related Proceedings Papers
Related Chapters
Introduction and scope
Impedimetric Biosensors for Medical Applications: Current Progress and Challenges
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices
Introduction
Modified Detrended Fluctuation Analysis (mDFA)