A comprehensive computational framework to simulate heat transfer during the freezing process in prostate cancer cryosurgery is presented. Tissues are treated as nonideal materials wherein phase transition occurs over a temperature range, thermophysical properties are temperature dependent and heating due to blood flow and metabolism are included. Boundary conditions were determined at the surfaces of the commercially available cryoprobes and urethral warmer by experimental study of temperature combined with a mathematical optimization process. For simulations, a suitable computational geometry was designed based on MRI imaging data of a real prostate. An enthalpy formulation-based numerical solution was performed for a prescribed surgical protocol to mimic a clinical freezing process. This computational framework allows for the individual planning of cryosurgical procedures and objective assessment of the effectiveness of prostate cryosurgery.
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e-mail: lxu@ecn.purdue.edu
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April 2005
Article
Numerical Simulation for Heat Transfer in Prostate Cancer Cryosurgery
Jiayao Zhang,
Jiayao Zhang
School of Mechanical Engineering
, Purdue University, West Lafayette, IN 47907
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George A. Sandison,
George A. Sandison
School of Health Science
, Purdue University, West Lafayette, IN 47907
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Jayathi Y. Murthy,
Jayathi Y. Murthy
School of Mechanical Engineering
, Purdue University, West Lafayette, IN 47907
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Lisa X. Xu
e-mail: lxu@ecn.purdue.edu
Lisa X. Xu
School of Mechanical Engineering and Department of Biomedical Engineering
, Purdue University, West Lafayette, IN 47907 and School of Life Sciences and Technology
, Shanghai Jiao Tong University, Shanghai, 200030, PRC
Search for other works by this author on:
Jiayao Zhang
School of Mechanical Engineering
, Purdue University, West Lafayette, IN 47907
George A. Sandison
School of Health Science
, Purdue University, West Lafayette, IN 47907
Jayathi Y. Murthy
School of Mechanical Engineering
, Purdue University, West Lafayette, IN 47907
Lisa X. Xu
School of Mechanical Engineering and Department of Biomedical Engineering
, Purdue University, West Lafayette, IN 47907 and School of Life Sciences and Technology
, Shanghai Jiao Tong University, Shanghai, 200030, PRCe-mail: lxu@ecn.purdue.edu
J Biomech Eng. Apr 2005, 127(2): 279-294 (16 pages)
Published Online: September 18, 2004
Article history
Received:
October 29, 2003
Revised:
September 18, 2004
Citation
Zhang, J., Sandison, G. A., Murthy, J. Y., and Xu, L. X. (September 18, 2004). "Numerical Simulation for Heat Transfer in Prostate Cancer Cryosurgery." ASME. J Biomech Eng. April 2005; 127(2): 279–294. https://doi.org/10.1115/1.1865193
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