The tri-structural isotropic (TRISO) fuel particles are utilized by High Temperature Gas-cooled Reactor (HTGR), which is important for the safety of HTGR. Recently, a new TRISO fuel performance code called FART is developed by the Institute of Nuclear and New Energy Technology (INET). FRAT employs more delicate models involving gas pressure buildup, mechanical stress analysis and the temperature and burnup effects. Furthermore, mechanical stress and failure probability are influenced by complex factors, such as geometric parameters, material properties and irradiation parameters. In addition, material properties and irradiation parameters are affected by temperature, fast neutron fluence, burnup, anisotropic factor and other parameters. In this paper, a comprehensive sensitivity study on influences of particle stress and failure probability from geometric, material and irradiation parameters of particle coating layers was performed. Results show that the calculated TRISO fuel failure probability is greatly affected by the input parameters. This work lays a ground for uncertainty quantification of FRAT code.