A previous study by the authors on fin-shape optimization of a plate fin heat sink has concluded that a depopulated central zone, just under the center of the fan, provides a better thermal performance compared to the heat sink geometries with fin material under the fan. This study extends the previous work by investigating the effect of removal of fin material from the end fins, the total number of fins, and the reduction in the size of the hub fan. From this study, it is concluded that the removal of fin material from the end fins results in a better thermal and hydraulic performance of the heat sink. The reduction in the size of the hub causes a more uniform distribution of air inside the heat sink. The increase in the number of fins indicates a slightly better thermal performance, accompanied by a considerably increased pressure drop. Finally, a new optimal heat sink design has been reported by employing the actual fan operating characteristics.